研究者情報
本学における所属
最終学歴
現在所属している学会
学士・修士・博士等の学位
研究者活動情報
研究分野
主な研究項目
主な著書
主な論文
その他の研究業績等
主な担当授業科目名
教育研究業績書情報(授業科目を担当する専任教員):職務上の実績に関する事項
資格,免許
基本情報
氏名
大西 敦
氏名(カナ)
オオニシ アツシ
氏名(英語)
Atsushi Ohnishi
所属
薬学部 薬学科
職名
教授
researchmap研究者コード
researchmap機関
本学における所属
帝京平成大学 薬学部 薬学科 教授
最終学歴
北海道大学 大学院地球環境科学研究科 生態環境科学専攻 博士課程 修了
現在所属している学会
日本動物学会
日本農芸化学会
日本薬学会
日本生化学会
学士・修士・博士等の学位
学士(教育学)、修士(地球環境科学)、博士(地球環境科学)
研究者活動情報
研究分野
基礎生物学、生物科学
主な研究項目
アミノペプチダーゼの基質認識機構に関する研究
ボンビコール産生メカニズムに関する研究
昆虫サイトカイン(ENFペプチド)の自然免疫への関与に関する研究
主な著書
Molecular Mechanisms of Insect Metamorphosis and Diapause 共著 Industrial Publishong & Consulting Inc. 1995/04
蛋白質核酸酵素 増刊ケミカルバイオロジー Vol.52 No.13 共著 共立出版 2007/04
入門ケミカルバイオロジー 共著 オーム社 2008/04
主な論文
Molecular cloning and characterization of cDNA for insect biogenic peptide,growth-blocking peptide. 共著 FEBS Letters 1995/12
Growth-blocking peptide titer during larval development of parasitized and cold-stressed armyworm. 共著
Insect Biochemistry and Molecular Biology
1995/12
Mechanism of parastism-induced elevation of hemolymph growth-blocking peptide levels in host insect larvae (
Pseudaletia separate
). 共著 Journal of Insect Physiology 1998/09
Cell growth activity of growth-blocking peptide. 共著 Biochemical and Biophysical Research Communications 1998/09
Solution structure of insect growth factor, growth-blocking peptide. 共著
Journal of Biological Chemistry
1999/01
全て表示する(41件)
Distribution of growth-blocking peptide in the insect central nervous tissue. 共著 Cell & Tissue Research 2000/06
Structure and activity of the insect cytokine growth-blocking peptide:Essential regions for mitogenic and hemocyte stimulatin 共著 The Journal of Biological Chemistry 2001/08
Characterization of receptors of insect cytokine,growth-blocking peptide,in human keratinocyte and insect Sf9 cells. 共著 The Journal of Biological Chemistry 2001/08
cDNA cloning of calcineurin heterosubunits from the pheromone gland of the silkmoth,Bombyx mori. 共著
Insect Biochemistry and Molecular Biology
2002/04
Cellular events and molecular mechanisms underlying sex pheromone production in female moths:Analysis in the silkworm,Bombyx 共著 Proceedingrs of the 21st Conference of Europian Comparative Endocrinologists 2002/04
Expression and purification of a small cytokine growth-blocking peptide from armyworm
Pseudaletia separata
by an optimized fermentation method using the methylotrophic yeast
Pichia pastoris.
共著 Protein Expression and Purification 2002/08
Cloning and characterization of the pheromone biosynthesis activating neuropeptide receptor from the silkmoth,
Bombyx mori
. Significance of the carboxyl terminus in receptor internalization
共著 The Journal of Biological Chemistry 2004/09
Isolation and characterization of a humoral factor that stimulates transcription of the acyl-CoA-binding protein in the pheromone gland of the silkmoth,
Bombyx mori
.
共著 The Journal of Biological Chemistry 2004/12
Further studies of lipid droplets in the bombykol-producing pheromone gland of
Bombyx mori
. 共著 Annals of the New York Academy of Sciences 2005/04
Regulatory mechanisms underlying pheromone biosynthesis activating neuropeptide (PBAN)-induced internalization of the
Bombyx mori
PBAN receptor.
共著 Biochemical and Biophysical Research Communications 2005/08
Targeted disruption of genes in the
Bombyx mori
sex pheromone biosynthetic pathway. 共著 Proceedings of the National Academy of Sciences of the United States of America 2006/03
Synthesis and biological activities of analogs of D-glucosyl-l-tyrosine, a humoral factor that stimulates transcription of the acyl-CoA binding protein in the pheromone gland of the Silkmoth,
Bombyx mori
.
共著 Bioorganic & Medicinal Chemistry 2006/10
Identification of a unique pheromonotropic neuropeptide including double FXPRL motifs from a geometrid species,
Ascotis selenaria cretacea
, which produces an epoxyalkenyl sex pheromone.
共著 Insect Biochemistry and Molecular Biology 2006/12
Determination of the pheromone-producing region that has epoxidation activity in the abdominal tip of the Japanese giant looper,
Ascotis selenaria cretacea
(Lepidoptera: Geometridae).
共著 Journal of Insect Physiology 2007/01
Molecular mechanisms underlying sex pheromone production in the silkmoth,
Bombyx mori
: characterization of the molecular components involved in bombykol biosynthesis.
共著 Journal of Insect Physiology 2007/03
Functional characterization of the
Bombyx mori
fatty acid transport protein (BmFATP) within the silkmoth pheromone gland.
共著 The Journal of Biological Chemistry 2008/12
Molecular mechanisms underlying PBAN signaling in the silkmoth B
ombyx mori.
共著 Annals of the New York Academy of Sciences 2009/04
Unraveling the pheromone biosynthesis activating neuropeptide (PBAN) signal transduction cascade that regulates sex pheromone production in moths.
共著
Vitamins & Hormones
2010/01
Adaptor protein is essential for insect cytokine signaling in hemocytes.
共著 Proceedings of the National Academy of Sciences of the United States of America 2010/08
RNA interference in Lepidoptera:an overview of successful and unsuccessful studies and implications for experimental design. 共著
Journal of Insect Physiology
2010/11
Studies of sex pheromone production under neuroendocrine control by analytical and morphological means in the oriental armyworm,
Pseudaletia separata
, Walker (Lepidoptera: Noctuidae).
共著
General and Comparative Endocrinology
2011/02
昆虫における性フェロモン生合成のホルモン制御:神経ホルモンPBANによるガ類性フェロモン産生の分子機構の全貌解明を目指して 共著 比較内分泌学 2011/04
Hormone signaling linked to silkmoth sex pheromone biosynthesis involves Ca
2+
/calmodulin-dependent protein kinase II-mediated phosphorylation of the insect PAT family protein
Bombyx mori
lipid storage droplet protein-1.
共著 The Journal of Biological Chemistry 2011/05
Screening for the Genes Involved in Bombykol Biosynthesis: Identification and Functional Characterization of
Bombyx mori
Acyl Carrier Protein.
共著 Frontiers in Endocrinology 2011/12
Drosophila growth-blocking peptide-like factor mediates acute immune reactions during infectious and non-infectious stress.
共著 Scientific Reports 2012/01
Characteristics common to a cytokine family spanning five orders of insects.
共著 Insect Biochemistry and Molecular Biology 2012/03
Role of glutamine-169 in the substrate recognition of human aminopeptidase B. 共著 Biochimica et Biophysics Acta (BBA) - General Subjects 2014/01
Involvement of phenylalanine-297 in the construction of the substrate pocket of human aminopeptidase B. 共著 Biochemistry 2015/10
ボンビコール産生系におけるフェロモン腺の脂肪滴ーその役割と動態制御ー 共著 蚕糸・昆虫バイオテック 2019/08
多機能性酵素としての小胞体アミノペプチダーゼ −ERAP研究の20年− 共著 生化学 2019/10
Endoplasmic Reticulum aminopeptidase 1 beyond antigenic peptide-processing enzyme in the Endoplasmic Reticulum.
共著 Biological and Pharmaceutical Bulletin 2020/02
部位特異的変異法を用いたアミノペプチダーゼBの酵素学的性状解析 共著 帝京平成大学紀要 2020/03
Importance of Tyr409 and Tyr414 in constructing the substrate pocket of human aminopeptidase B. 共著 Molecular and Cellular Biochemistry 2020/06
Molecular and functional diversity of The oxytocinase subfamily of M1 aminopeptidases. 共著 The Journal of Biochemistry 2021/04
Characterization of the enzymatic properties of human RNPEPL1/aminopeptidase Z
/Joint Author/The Journal of Biochemistry/2023/04
Distinguishing two distinct types of salivary extracellular vesicles: a potential tool for understanding their pathophysiological roles.
/Joint Author/
Frontiers in Molecular Biosciences
/2024/02
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その他の研究業績等
 
主な担当授業科目名
遺伝子の構造・機能
基礎実習Ⅰ
分子生物薬学特講
タンパク質の構造・機能
基礎薬学総合演習
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卒業研究
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