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Basic information
| Name |
Shun'ichi Shimizu |
| Belonging department |
Department of Pharmaceutical Sciences,Faculty of Pharmaceutical Sciences |
| Occupation name |
Professor |
| researchmap researcher code |
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| researchmap agency |
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Affiliation of Our College |
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Last Educational Background |
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The Academic Society which Belongs at Present |
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Researcher Activity Information
- Chemotherapy-induced neutropenia as a prognostic factor in patients with unresectable pancreatic cancer. 共著 Cancer Chemother Pharmacol., 76, 1217-1224 2015/12
- Identification of regulatory sites in the biosynthesis of ubiquinone in the perfused rat heart. 共著 Arch. Biochem. Biophys., 269, 86-92 1989/01
- Possible existence of an intermediate pool of ubiquinone in rat heart mitochondria. 共著 Int. J. Biochem., 22, 89-91 1990/01
- Inhibition of ubiquinone synthesis in isolated rat heart under an ischemic condition. 共著 Int. J. Biochem., 22, 477-480 1990/05
- Possible involvement of 3-hydroxymethylglutaryl-CoA reductase in determining the side-chain length of ubiquinone in rat heart. 共著 Arch. Biochem. Biophys., 284, 35-39 1991/02
- Inhibition by methylene blue of the L-arginine metabolism to L-citrulline coupled with nitric oxide synthesis in cultured endothelial cells. 共著 Res. Commun. Chem. Pathol. Pharmacol., 82, 35-48 1993/10
- Stimulation by hydrogen peroxide of L-arginine metabolism to L-citrulline coupled with nitric oxide synthesis in cultured endothelial cells. 共著 Res. Commun. Chem. Pathol. Pharmacol., 84, 315-329 1994/06
- Bradykinin induces generation of reactive oxygen species in bovine aortic endothelial cells. 共著 Res. Commun. Chem. Pathol. Pharmacol., 84, 301-314 1994/06
- Reduction by NG-nitro-L-arginine of H2O2-induced endothelial cell injury. 共著 Br. J. Pharmacol., 113, 564-568 1994/10
- The effects of hypoxia on pHi in porcine coronary artery endothelium and smooth muscle. A novel method for measurement in endothelial cell in situ. 共著 Circ. Res., 80, 21-27 1997/01
- Acceleration of oxidative stress-induced endothelial cell death by nitric oxide synthase dysfunction accompanied with decrease in tetrahydrobiopterin content. 共著 Life Sci., 61, 739-747 1997/02
- Mechanism of nitric oxide production induced by H2O2 in cultured endothelial cells. 共著 Res. Commun. Chem. Pathol. Pharmacol., 95, 227-239 1997/03
- The endothelium-dependent, substance P relaxation of porcine coronary arteries resistant to nitric oxide synthesis inhibition is partially mediated by 4-aminopyridine-sensitive voltage-dependent K+ channels. 共著 Endothelium, 5, 287-295 1997/04
- Possible involvement of nitric oxide synthase in oxidative stress-induced endothelial cell injury. 共著 Pharmacol. Toxicol., 80, 191-196 1997/04
- Changes in nitric oxide synthase activity during exposure to hydrogen peroxide in cultured endothelial cells. 共著 Res. Commun. Chem. Pathol. Pharmacol., 97, 279-289 1997/09
- Cold storage induces an endothelium-independent relaxation to hypoxia/reoxygenation in porcine coronary arteries. 共著 J. Vasc. Res., 34, 399-407 1997/09
- Reduction by tetrahydrobiopterin of H2O2-induced endothelial cell injury. 共著 Pharmacol. Toxicol., 82, 280-286 1998/01
- Stimulation of nitric oxide synthase during oxidative endothelial cell injury. 共著 Biochem. Pharmacol., 55, 77-83 1998/01
- Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells. 共著 Am. J. Physiol., 274, C472-C480 1998/02
- Protective effects of tetrahydrobiopterin against nitric oxide induced endothelial cell death. 共著 Life Sci., 63, 1585-1592 1998/02
- Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. 共著 J. Biol. Chem., 273, 10279-10287 1998/04
- Insulin stimulates tetrahydrobiopterin synthesis in mouse brain microvascular endothelial cells. 共著 Pteridines, 10, 213-216 1999/01
- Stimulation of in vitro angiogenesis by hydrogen peroxide and the relation with ETS-1 in endothelial cells. 共著 Life Sci., 64, 249-258 1999/01
- Stimulation of in vitro angiogenesis by tetrahydrobiopterin in bovine aortic endothelial cells. 共著 Jpn. J. Pharmacol., 80, 177-180 1999/01
- Characterization of the protective effect of tetrahydrobiopterin against S-nitroso-N-acetyl-D,L-penicillamine induced endothelial cell injury. 共著 Pteridines, 10, 14-19 1999/01
- SIN-1-induced cytotoxicity in cultured endothelial cells involves reactive oxygen species and nitric oxide: protective effect of sepiapterin. 共著 J. Cardiovasc. Pharmacol., 33, 295-300 1999/02
- Presence of excess tetrahydrobiopterin during nitric oxide production from inducible nitric oxide synthase in LPS-treated rat aorta. 共著 Life Sci., 65, 2769-2779 1999/02
- [Ca2+]i homeostasis and cyclic nucleotide relaxation in aorta of phospholamban-deficient mice. 共著 Am. J. Physiol., 277, H963-H970 1999/09
- Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. 共著 J. Biol. Chem., 274, 27359-27370 1999/09
- Hypoxia and alkalinization inhibit endothelium-derived nitric oxide but not endothelium-derived hyperpolarizing factor responses in porcine coronary artery. 共著 J. Pharmacol. Exp. Ther., 291, 335-344 1999/10
- Troglitazone stimulates the insulin-induced tetrahydrobiopterin synthesis in vascular endothelial cells. 共著 Pteridines, 11, 137-141 2000/01
- Stimulation of tetrahydrobiopterin synthesis by 17β-estradiol in brain microvascular endothelial cells. 共著 Pteridines, 11, 129-132 2000/01
- Involvement of reactive oxygen species and nitric oxide in gastric ischemia-reperfusion injury in rats. 共著 Dig. Dis. Sci., 45, 93-98 2000/01
- Role of voltage-dependent and Ca2+-activated K+ channels on the regulation of isometric force in porcine coronary artery. 共著 J. Vasc. Res., 37, 16-25 2000/01
- Effects of hypoxia on isometric force, intracellular Ca2+, pH, and energetics in porcine coronary artery. 共著 Circ. Res., 86, 862-870 2000/04
- A novel effect of polymorphonuclear leukocytes in the facilitation of angiogenesis. 共著 Life Sci., 66, 2113-2121 2000/05
- Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase. 共著 Int. J. Biochem. Cell Biol., 33, 65-73 2001/01
- Negative regulation of insulin-induced tetrahydrobiopterin synthesis by protein kinase C in vascular endothelial cells. 共著 Pteridines, 12, 161-166 2001/01
- The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha1-adrenoceptor-activated Ca2+-permeable cation channel. 共著 Circ. Res., 88, 325-332 2001/02
- Hypoxic vasodilation in porcine coronary artery is preferentially inhibited by organ culture. 共著 Am. J. Physiol., 281, C24-C32 2001/07
- Carboxy-PTIO increases the tetrahydrobiopterin level in mouse brain microvascular endothelial cells. 共著 Jpn. J. Pharmacol., 87, 51-60 2001/09
- LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. 共著 Mol. Cell, 9, 163-173 2002/01
- Stimulation of tetrahydrobiopterin synthesis by cyclosporin A during lipopolysaccharide treatment in vascular endothelial cells. 共著 Pteridines, 13, 89-93 2002/01
- Hydrogen peroxide stimulates the LPS-induced tetrahydrobiopterin synthesis in mouse brain microvascular endothelial cells. 共著 Pteridines, 13, 21-25 2002/01
- Ets-1 upregulates matrix metalloproteinase-1 expression through extracellular matrix adhesion in vascular endothelial cells. 共著 Biochem. Biophys. Res. Commun., 291, 130-138 2002/02
- Differential roles of ICAM-1 and E-selectin in polymorphonuclear leukocyte-induced angiogenesis. 共著 Am. J. Physiol., 282, C917-C925 2002/04
- Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells. 共著 Int. J. Biochem. Cell Biol., 34, 1134-1141 2002/09
- Stimulation of tetrahydrobiopterin synthesis by basic fibroblast growth factor in vascular endothelial cells. 共著 Pteridines, 14, 9-12 2003/01
- Decrease in tetrahydrobiopterin content promotes L-arginine-induced elevation of cytosolic calcium concentration in insulin-secreting cells. 共著 Pteridines, 14, 119-125 2003/01
- Stimulation of tetrahydrobiopterin synthesis by peroxynitrite in vascular endothelial cells. 共著 Pteridines, 14, 114-118 2003/01
- Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells. 共著 Free Radic. Biol. Med., 34, 1343-1352 2003/03
- Stimulation of in vitro angiogenesis by nitric oxide through the induction of transcription factor ETS-1. 共著 Int. J. Biochem. Cell Biol., 36, 114-122 2004/01
- Reduction of GTP cyclohydrolase I feedback regulating protein expression by hydrogen peroxide in vascular endothelial cells. 共著 J. Pharmacol. Sci., 97, 299-302 2005/02
- Possible involvement of hydroxyl radical on the stimulation of tetrahydrobiopterin synthesis by hydrogen peroxide and peroxynitrite in vascular endothelial cells. 共著 Int. J. Biochem. Cell Biol., 37, 864-875 2005/04
- Intracellular-produced hydroxyl radical mediates H2O2-induced Ca2+ influx and cell death in rat β-cell line RIN-5F. 共著 Cell Calcium, 39, 487-494 2006/01
- Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells. 共著 J. Physiol., 570, 219-235 2006/01
- Extracellular-added ADP-ribose increases intracellular free Ca2+ concentration through Ca2+ release from stores, but not through TRPM2-mediated Ca2+ entry, in rat b-cell line RIN-5F. 共著 J. Pharmacol. Sci., 101, 174-178 2006/01
- Tetrahydrobiopterin regulates L-tyrosine-induced elevation of cytosolic calcium concentration in insulin-secreting cells. 共著 Pteridines, 17, 69-73 2006/01
- Reduction of myocardial infarct size by tetrahydrobiopterin: Possible involvement of mitochondrial KATP channels activation through nitric oxide production. 共著 J. Cardiovasc. Pharmacol., 47, 243-249 2006/02
- Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children. 共著 Pediatr. Allergy Immunol., 17, 583-590 2006/12
- Nitric oxide activates TRP channels by cysteine S-nitrosylation. 共著 Nat. Chem. Biol., 2, 596-607 2006/12
- Facilitation of H2O2-induced A172 human glioblastoma cell death by insertion of oxidative stress-sensitive TRPM2 channels. 共著 Anticancer Res., 27, 3987-3992 2007/11
- Insulin secretion in response to L-arginine under decreasing tetrahydrobiopterin content. 共著 Pteridines, 19, 93-100 2008/01
- Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells. 共著 Int. J. Biochem. & Cell Biol., 40, 755-765 2008/04
- TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. 共著 Nat. Med., 14, 738-747 2008/07
- Inhibitory effect of lomerizine , a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery. 共著 J. Pharmacol. Sci., 111, 221-225 2009/10
- An important role of increase in tetrahydrobiopterin via H2O2/Jak2 signaling pathway in late phase of ischaemic preconditioning. 共著 Exp. Physiol., 95, 609-621 2010/03
- Association of the A-1483G polymorphism in serotonin 2A receptor in migraine with aura among Japanese patients. 共著 Biol. Pharm. Bull., 33, 1751-1753 2010/10
- Impaired Ca2+ regulation of CD4+CD25+ regulatory Y cells from pediatric asthma. 共著 Int. Arch. Allergy Immunol.,156, 148-158 2011/02
- Negative predictors of clinical response to triptans in patients with migraine. 共著 Neurol. Sci., 33, 453-461 2011/04
- AW551984: a novel regulator of cardiomyogenesis in pluripotent embryonic cells. 共著 Biochem. J. 437, 345-355 2011/07
- Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity. 共著 Mol. Cell. Biochem. 358, 1-11 2011/12
- Possible involvement of transient receptor potential channels in electrophile-induced insulin secretion from RINm5F cells. 共著 Biol. Pharm. Bull., 35, 346-354 2012/03
- MAOA, MTHFR, and TNF-genes polymorphisms and personality traits in the pathogenesis of migraine. 共著 Mol. Cell. Biochem., 363, 357-366 2012/04
- Association between the G252A Tumor Necrosis Factor-β Gene Polymorphism and Medication-Overuse Headache. 共著 J Clin Neurol., 8, 301-304 2012/12
- Predictive index for the onset of medication overuse headache in migraine patients. 共著 Neurol. Sci. 34, 85-92 2013/01
- Metformin Modulates GLP-1- and GIP-Mediated Intracellular Signaling under Normoglycemic Conditions. 共著 Open J. Endo. Metabolic Dis., 3, 263-270 2013/01
- Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury. 共著 Cardiovasc. Res., 97, 271-281, 2013 2013/02
- Decreased cardiac mitochondrial tetrahydrobiopterin in a rat model of pressure overload. 共著 Int. J. Mol. Med., 31, 589-596, 2013 2013/03
- Tryptophan Hydroxylase 2 Gene Polymorphisms in Japanese Patients with Medication Overuse Headaches. 共著 Acta Neurol Taiwan, 22, 147-151, 2013 2013/12
- Characteristics of inconsistent responders to prophylaxis therapy with lomerizine in patients with migraine: A retrospective st 共著 J. Neurol. Sci., 335, 118-123, 2013 2013/12
- Potentiated macrophage activation by acid sensing under low adiponectin levels. 共著 Mol. Immunol., 57, 141-150, 2014 2014/02
- Polymorphisms of nitric oxide synthase and GTP cyclohydrolase I genes in Japanese patients with medication overuse headaches. 共著 Neurology Asis, 19, 277-281, 2014 2014/03
- Involvement of TRPM2 and L-type Ca2+ channels in Ca2+ entry and cell death induced by hydrogen peroxide in rat -cell line RIN-5 共著 J Toxicol Sci, 39, 199-209, 2014 2014/04
- Influence of the Tohoku-Pacific Ocean Earthquake and Its Aftershocks on the Response to Prophylactic Therapy with Lomerizine in 共著 Eur. Neurol., 71, 252–258, 2014 2014/05
- MAOA and TNF-gene polymorphisms are associated with photophobia but not osmophobia in patients with migraine. 共著 Acta Neurol Taiwan, 23, 40-48, 2014 2014/06
- Elevated receptor for activated C kinase 1 expression is involved in intracellular Ca2+ influx and potentially associated with 共著 Clin Exp Allergy, 44, 1154-1169, 2014 2014/09
- Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry. 共著 Eur J Pharmacol, 742, 22-30, 2014 2014/11
- A cyclooxygenase 2 gene polymorphism is a risk factor for the complication of medication overuse headaches in patients with mig 共著 J Neurol Disord, 3 (1), doi.prg/10.4172/2329-6895.1000206, 2015 2015/02
- Practical prognostic index for survival in patients with unresectable pancreatic cancer treated with gemcitabine or S-1. 共著 Hepatogastroenterology 2015/03
- TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation. 共著 Free Radic Biol & Med., 90, 101–113 2015/11
- Inhibitory effects of Tyrphostin AG-related compounds on oxidative stress-sensitive transient receptor potential channel activa 共著 Eur J Pharmacol., 786, 19-28 2016/05
- Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe2+ in human m 共著 Int J Biochem & Cell Biol., 68, 119-127 2016/11
- Tyrphostin AG-related compounds attenuate H2O2-induced TRPM2-dependent and -independent cellular responses. 共著 J Pharmacol Sci., 134, 68-74 2017/05
- デュロキセチンによるTRPM2チャネル遮断を介した脳虚血-再灌流障害の抑制/Joint Author/J. Pharmacol.Exp. Ther., 368, 246-254/2019/02
- Short TRPM2 prevents the targeting of full-length TRPM2 to the surface transmembrane by hijacking to ER associated degradation. 共著 Biochem Biophys Res Commun., 520, 520-525, 2019. 2019/10
- Possible involvement of TRPM2 activation in 5-fluorouracil-induced myelosuppression in mice. 共著 Eur J Pharmacol., 891, 173671, 2021. doi : 10.1016/j.ejphar.2020.173671 2021/01
- Mouse transient receptor potential melastatin 2 (TRPM2) isoform 7 attenuates full-length mouse TRPM2 activity through reductions in its expression by targeting it to ER-associated degradation./Joint Author/Genes cells, 29, 254-269/2024/01
Other Research Achievements |
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- Role of tetrahydrobiopterin in the function of nitric oxide synthase, and its cytoprotective effect (Review). 共著 1998/11 Int. J. Mol. Med., 2, 533-540, 1998.
- 血管内皮由来過分極因子はK+？ 単著 1999/01 ファルマシア, 35, 944-945, 1999
- Receptor-activated Ca2+ influx: capacitative Ca2+ entry and TRP proteins. 共著 1999/09 Nippon Yakurigaku Zasshi, 114, 149-160, 1999
- Protective effect of tetrahydrobiopterin against reactive oxygen species- and nitric oxide-induced vascular endothelial cell injury. 単著 2002/01 Pteridines, 13, 32-37, 2002
- Ca2+ channel alpha1B subunit (CaV 2.2) knockout mouse reveals a predominant role of N-type channels in the sympathetic regulation of the circulatory system. 共著 2002/06 Trends Cardiovasc. Med., 12, 270-274
Education research achievement book information (full-time teacher in charge of course subjects): Matters related to job performance
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