Papers

Basic information

Name Shun'ichi Shimizu
Belonging department Department of Pharmaceutical Sciences,Faculty of Pharmaceutical Sciences
Occupation name Professor
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Title 

デュロキセチンによるTRPM2チャネル遮断を介した脳虚血-再灌流障害の抑制

					

					

						

							

								

									
Bibliography　Type 

									
								

							

						

						
Joint Author

					

					

						

							

								

									
Summary 

									
								

							

						

						
Activation of transient receptor potential melastatin 2 (TRPM2), an oxidative stress–sensitive Ca2+-permeable channel, contributes to the aggravation of cerebral ischemia-reperfusion (CIR) injury. We found that antidepressant duloxetine has strong inhibitory effects on TRPM2 activation, and reduces CIR injury in mice. 

					

					

						

							

								

									
Magazine(name) 

									
								

							

						

						
J. Pharmacol.Exp. Ther., 368, 246-254

					

					

						

							

								

									
Date of Issue 

									
								

							

						

						
201902