研究者情報
本学における所属
最終学歴
現在所属している学会
学士･修士･博士等の学位
研究者活動情報
研究分野
主な研究項目
主な著書
主な論文
その他の研究業績等
主な担当授業科目名
教育研究業績書情報（授業科目を担当する専任教員）：職務上の実績に関する事項
資格，免許
基本情報
氏名
清水 俊一
氏名（カナ）
シミズ シュンイチ
氏名（英語）
Shun'ichi Shimizu
所属
薬学部 薬学科
職名
教授
researchmap研究者コード
researchmap機関
本学における所属
帝京平成大学 薬学部 薬学科 教授
最終学歴
昭和大学大学院薬学研究科博士前期課程
現在所属している学会
日本生化学会
日本薬学会
日本薬理学会
学士･修士･博士等の学位
博士（薬学）
研究者活動情報
研究分野
生物系薬学、薬理学一般
主な研究項目
炎症性疾患におけるTRPチャネルの役割
活性酸素感受性TRPチャネルの役割
TRPチャネル阻害剤の探索とその応用
主な著書
Angiogenesis induced by adhesion between polymorphonuclear leukocyte and endothelial cell via intercellular adhesion mol 共著 New Frontiers in Regenerative Medicine. 2007/06
Immune mechanisms of childhood asthma. 共著 InTech-Open Access Publisher 2011/06
イラストでみる疾病の成り立ちと薬物療法 共著 医学評論社 2013/09
TRPs as Chemosensors (ROS, RNS, RCS, Gasotransmitters). 共著 Mammalian Transient Receptor Potential (TRP) Cation Channels, Handbook of Experimental Pharmacology 223, pp. 767-794, Springer International Publishing Switzerland 2014/07
構造式手帳 共著 京都廣川書店 2016/03
全て表示する（8件）
Targeting TRPM2 in ROS-coupled diseases. 共著 Pharmaceuticals, doi:10.3390/ph9030057 2016/09
Significance of TRP channels in oxidative stress. 共著 Eur J Pharmacol., 793, 109-111 2016/11
アルティメイト薬理学 共編者( 共編著者) 京都廣川書店 2022/03
表示を折りたたむ
主な論文
Chemotherapy-induced neutropenia as a prognostic factor in patients with unresectable pancreatic cancer. 共著 Cancer Chemother Pharmacol., 76, 1217-1224 2015/12
Identification of regulatory sites in the biosynthesis of ubiquinone in the perfused rat heart. 共著 Arch. Biochem. Biophys., 269, 86-92 1989/01
Possible existence of an intermediate pool of ubiquinone in rat heart mitochondria. 共著 Int. J. Biochem., 22, 89-91 1990/01
Inhibition of ubiquinone synthesis in isolated rat heart under an ischemic condition. 共著 Int. J. Biochem., 22, 477-480 1990/05
Possible involvement of 3-hydroxymethylglutaryl-CoA reductase in determining the side-chain length of ubiquinone in rat heart. 共著 Arch. Biochem. Biophys., 284, 35-39 1991/02
全て表示する（98件）
Inhibition by methylene blue of the L-arginine metabolism to L-citrulline coupled with nitric oxide synthesis in cultured endothelial cells. 共著 Res. Commun. Chem. Pathol. Pharmacol., 82, 35-48 1993/10
Stimulation by hydrogen peroxide of L-arginine metabolism to L-citrulline coupled with nitric oxide synthesis in cultured endothelial cells. 共著 Res. Commun. Chem. Pathol. Pharmacol., 84, 315-329 1994/06
Bradykinin induces generation of reactive oxygen species in bovine aortic endothelial cells. 共著 Res. Commun. Chem. Pathol. Pharmacol., 84, 301-314 1994/06
Reduction by NG-nitro-L-arginine of H
2
O
2
-induced endothelial cell injury. 共著 Br. J. Pharmacol., 113, 564-568 1994/10
The effects of hypoxia on pH
i
in porcine coronary artery endothelium and smooth muscle. A novel method for measurement in endothelial cell in situ. 共著 Circ. Res., 80, 21-27 1997/01
Acceleration of oxidative stress-induced endothelial cell death by nitric oxide synthase dysfunction accompanied with decrease in tetrahydrobiopterin content. 共著 Life Sci., 61, 739-747 1997/02
Mechanism of nitric oxide production induced by H
2
O
2
in cultured endothelial cells. 共著 Res. Commun. Chem. Pathol. Pharmacol., 95, 227-239 1997/03
The endothelium-dependent, substance P relaxation of porcine coronary arteries resistant to nitric oxide synthesis inhibition is partially mediated by 4-aminopyridine-sensitive voltage-dependent K
+
channels. 共著 Endothelium, 5, 287-295 1997/04
Possible involvement of nitric oxide synthase in oxidative stress-induced endothelial cell injury. 共著 Pharmacol. Toxicol., 80, 191-196 1997/04
Changes in nitric oxide synthase activity during exposure to hydrogen peroxide in cultured endothelial cells. 共著 Res. Commun. Chem. Pathol. Pharmacol., 97, 279-289 1997/09
Cold storage induces an endothelium-independent relaxation to hypoxia/reoxygenation in porcine coronary arteries. 共著 J. Vasc. Res., 34, 399-407 1997/09
Reduction by tetrahydrobiopterin of H
2
O
2
-induced endothelial cell injury. 共著 Pharmacol. Toxicol., 82, 280-286 1998/01
Stimulation of nitric oxide synthase during oxidative endothelial cell injury. 共著 Biochem. Pharmacol., 55, 77-83 1998/01
Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells. 共著 Am. J. Physiol., 274, C472-C480 1998/02
Protective effects of tetrahydrobiopterin against nitric oxide induced endothelial cell death. 共著 Life Sci., 63, 1585-1592 1998/02
Molecular cloning and functional characterization of a novel receptor-activated TRP Ca
2+
channel from mouse brain. 共著 J. Biol. Chem., 273, 10279-10287 1998/04
Insulin stimulates tetrahydrobiopterin synthesis in mouse brain microvascular endothelial cells. 共著 Pteridines, 10, 213-216 1999/01
Stimulation of in vitro angiogenesis by hydrogen peroxide and the relation with ETS-1 in endothelial cells. 共著 Life Sci., 64, 249-258 1999/01
Stimulation of in vitro angiogenesis by tetrahydrobiopterin in bovine aortic endothelial cells. 共著 Jpn. J. Pharmacol., 80, 177-180 1999/01
Characterization of the protective effect of tetrahydrobiopterin against S-nitroso-N-acetyl-D,L-penicillamine induced endothelial cell injury. 共著 Pteridines, 10, 14-19 1999/01
SIN-1-induced cytotoxicity in cultured endothelial cells involves reactive oxygen species and nitric oxide: protective effect of sepiapterin. 共著 J. Cardiovasc. Pharmacol., 33, 295-300 1999/02
Presence of excess tetrahydrobiopterin during nitric oxide production from inducible nitric oxide synthase in LPS-treated rat aorta. 共著 Life Sci., 65, 2769-2779 1999/02
[Ca
2+
]
i
homeostasis and cyclic nucleotide relaxation in aorta of phospholamban-deficient mice. 共著 Am. J. Physiol., 277, H963-H970 1999/09
Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. 共著 J. Biol. Chem., 274, 27359-27370 1999/09
Hypoxia and alkalinization inhibit endothelium-derived nitric oxide but not endothelium-derived hyperpolarizing factor responses in porcine coronary artery. 共著 J. Pharmacol. Exp. Ther., 291, 335-344 1999/10
Troglitazone stimulates the insulin-induced tetrahydrobiopterin synthesis in vascular endothelial cells. 共著 Pteridines, 11, 137-141 2000/01
Stimulation of tetrahydrobiopterin synthesis by 17β-estradiol in brain microvascular endothelial cells. 共著 Pteridines, 11, 129-132 2000/01
Involvement of reactive oxygen species and nitric oxide in gastric ischemia-reperfusion injury in rats. 共著 Dig. Dis. Sci., 45, 93-98 2000/01
Role of voltage-dependent and Ca
2+
-activated K
+
channels on the regulation of isometric force in porcine coronary artery. 共著 J. Vasc. Res., 37, 16-25 2000/01
Effects of hypoxia on isometric force, intracellular Ca
2+
, pH, and energetics in porcine coronary artery. 共著 Circ. Res., 86, 862-870 2000/04
A novel effect of polymorphonuclear leukocytes in the facilitation of angiogenesis. 共著 Life Sci., 66, 2113-2121 2000/05
Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase. 共著 Int. J. Biochem. Cell Biol., 33, 65-73 2001/01
Negative regulation of insulin-induced tetrahydrobiopterin synthesis by protein kinase C in vascular endothelial cells. 共著 Pteridines, 12, 161-166 2001/01
The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha
1
-adrenoceptor-activated Ca
2+
-permeable cation channel. 共著 Circ. Res., 88, 325-332 2001/02
Hypoxic vasodilation in porcine coronary artery is preferentially inhibited by organ culture. 共著 Am. J. Physiol., 281, C24-C32 2001/07
Carboxy-PTIO increases the tetrahydrobiopterin level in mouse brain microvascular endothelial cells. 共著 Jpn. J. Pharmacol., 87, 51-60 2001/09
LTRPC2 Ca
2+
-permeable channel activated by changes in redox status confers susceptibility to cell death. 共著 Mol. Cell, 9, 163-173 2002/01
Stimulation of tetrahydrobiopterin synthesis by cyclosporin A during lipopolysaccharide treatment in vascular endothelial cells. 共著 Pteridines, 13, 89-93 2002/01
Hydrogen peroxide stimulates the LPS-induced tetrahydrobiopterin synthesis in mouse brain microvascular endothelial cells. 共著 Pteridines, 13, 21-25 2002/01
Ets-1 upregulates matrix metalloproteinase-1 expression through extracellular matrix adhesion in vascular endothelial cells. 共著 Biochem. Biophys. Res. Commun., 291, 130-138 2002/02
Differential roles of ICAM-1 and E-selectin in polymorphonuclear leukocyte-induced angiogenesis. 共著 Am. J. Physiol., 282, C917-C925 2002/04
Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells. 共著 Int. J. Biochem. Cell Biol., 34, 1134-1141 2002/09
Stimulation of tetrahydrobiopterin synthesis by basic fibroblast growth factor in vascular endothelial cells. 共著 Pteridines, 14, 9-12 2003/01
Decrease in tetrahydrobiopterin content promotes L-arginine-induced elevation of cytosolic calcium concentration in insulin-secreting cells. 共著 Pteridines, 14, 119-125 2003/01
Stimulation of tetrahydrobiopterin synthesis by peroxynitrite in vascular endothelial cells. 共著 Pteridines, 14, 114-118 2003/01
Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells. 共著 Free Radic. Biol. Med., 34, 1343-1352 2003/03
Stimulation of in vitro angiogenesis by nitric oxide through the induction of transcription factor ETS-1. 共著 Int. J. Biochem. Cell Biol., 36, 114-122 2004/01
Reduction of GTP cyclohydrolase I feedback regulating protein expression by hydrogen peroxide in vascular endothelial cells. 共著 J. Pharmacol. Sci., 97, 299-302 2005/02
Possible involvement of hydroxyl radical on the stimulation of tetrahydrobiopterin synthesis by hydrogen peroxide and peroxynitrite in vascular endothelial cells. 共著 Int. J. Biochem. Cell Biol., 37, 864-875 2005/04
Intracellular-produced hydroxyl radical mediates H
2
O
2
-induced Ca
2+
influx and cell death in rat β-cell line RIN-5F. 共著 Cell Calcium, 39, 487-494 2006/01
Ca
2+
-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells. 共著 J. Physiol., 570, 219-235 2006/01
Extracellular-added ADP-ribose increases intracellular free Ca
2+
concentration through Ca
2+
release from stores, but not through TRPM2-mediated Ca
2+
entry, in rat b-cell line RIN-5F. 共著 J. Pharmacol. Sci., 101, 174-178 2006/01
Tetrahydrobiopterin regulates L-tyrosine-induced elevation of cytosolic calcium concentration in insulin-secreting cells. 共著 Pteridines, 17, 69-73 2006/01
Reduction of myocardial infarct size by tetrahydrobiopterin: Possible involvement of mitochondrial K
ATP
channels activation through nitric oxide production. 共著 J. Cardiovasc. Pharmacol., 47, 243-249 2006/02
Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children. 共著 Pediatr. Allergy Immunol., 17, 583-590 2006/12
Nitric oxide activates TRP channels by cysteine S-nitrosylation. 共著 Nat. Chem. Biol., 2, 596-607 2006/12
Facilitation of H
2
O
2
-induced A172 human glioblastoma cell death by insertion of oxidative stress-sensitive TRPM2 channels. 共著 Anticancer Res., 27, 3987-3992 2007/11
Insulin secretion in response to L-arginine under decreasing tetrahydrobiopterin content. 共著 Pteridines, 19, 93-100 2008/01
Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells. 共著 Int. J. Biochem. & Cell Biol., 40, 755-765 2008/04
TRPM2-mediated Ca
2+
influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. 共著 Nat. Med., 14, 738-747 2008/07
Inhibitory effect of lomerizine , a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery. 共著 J. Pharmacol. Sci., 111, 221-225 2009/10
An important role of increase in tetrahydrobiopterin via H
2
O
2
/Jak2 signaling pathway in late phase of ischaemic preconditioning. 共著 Exp. Physiol., 95, 609-621 2010/03
Association of the A-1483G polymorphism in serotonin 2A receptor in migraine with aura among Japanese patients. 共著 Biol. Pharm. Bull., 33, 1751-1753 2010/10
Impaired Ca
2+
regulation of CD4
+
CD25
+
regulatory Y cells from pediatric asthma. 共著 Int. Arch. Allergy Immunol.,156, 148-158 2011/02
Negative predictors of clinical response to triptans in patients with migraine. 共著 Neurol. Sci., 33, 453-461 2011/04
AW551984: a novel regulator of cardiomyogenesis in pluripotent embryonic cells. 共著 Biochem. J. 437, 345-355 2011/07
Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity. 共著 Mol. Cell. Biochem. 358, 1-11 2011/12
Possible involvement of transient receptor potential channels in electrophile-induced insulin secretion from RINm5F cells. 共著 Biol. Pharm. Bull., 35, 346-354 2012/03
MAOA, MTHFR, and TNF-genes polymorphisms and personality traits in the pathogenesis of migraine. 共著 Mol. Cell. Biochem., 363, 357-366 2012/04
Association between the G252A Tumor Necrosis Factor-β Gene Polymorphism and Medication-Overuse Headache. 共著 J Clin Neurol., 8, 301-304 2012/12
Predictive index for the onset of medication overuse headache in migraine patients. 共著 Neurol. Sci. 34, 85-92 2013/01
Metformin Modulates GLP-1- and GIP-Mediated Intracellular Signaling under Normoglycemic Conditions. 共著 Open J. Endo. Metabolic Dis., 3, 263-270 2013/01
Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury. 共著 Cardiovasc. Res., 97, 271-281, 2013 2013/02
Decreased cardiac mitochondrial tetrahydrobiopterin in a rat model of pressure overload. 共著 Int. J. Mol. Med., 31, 589-596, 2013 2013/03
Tryptophan Hydroxylase 2 Gene Polymorphisms in Japanese Patients with Medication Overuse Headaches. 共著 Acta Neurol Taiwan, 22, 147-151, 2013 2013/12
Characteristics of inconsistent responders to prophylaxis therapy with lomerizine in patients with migraine: A retrospective st 共著 J. Neurol. Sci., 335, 118-123, 2013 2013/12
Potentiated macrophage activation by acid sensing under low adiponectin levels. 共著 Mol. Immunol., 57, 141-150, 2014 2014/02
Polymorphisms of nitric oxide synthase and GTP cyclohydrolase I genes in Japanese patients with medication overuse headaches. 共著 Neurology Asis, 19, 277-281, 2014 2014/03
Involvement of TRPM2 and L-type Ca2+ channels in Ca2+ entry and cell death induced by hydrogen peroxide in rat -cell line RIN-5 共著 J Toxicol Sci, 39, 199-209, 2014 2014/04
Influence of the Tohoku-Pacific Ocean Earthquake and Its Aftershocks on the Response to Prophylactic Therapy with Lomerizine in 共著 Eur. Neurol., 71, 252–258, 2014 2014/05
MAOA and TNF-gene polymorphisms are associated with photophobia but not osmophobia in patients with migraine. 共著 Acta Neurol Taiwan, 23, 40-48, 2014 2014/06
Elevated receptor for activated C kinase 1 expression is involved in intracellular Ca2+ influx and potentially associated with 共著 Clin Exp Allergy, 44, 1154-1169, 2014 2014/09
Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry. 共著 Eur J Pharmacol, 742, 22-30, 2014 2014/11
A cyclooxygenase 2 gene polymorphism is a risk factor for the complication of medication overuse headaches in patients with mig 共著 J Neurol Disord, 3 (1), doi.prg/10.4172/2329-6895.1000206, 2015 2015/02
Practical prognostic index for survival in patients with unresectable pancreatic cancer treated with gemcitabine or S-1. 共著 Hepatogastroenterology 2015/03
TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation. 共著 Free Radic Biol & Med., 90, 101–113 2015/11
Inhibitory effects of Tyrphostin AG-related compounds on oxidative stress-sensitive transient receptor potential channel activa 共著 Eur J Pharmacol., 786, 19-28 2016/05
Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe2+ in human m 共著 Int J Biochem & Cell Biol., 68, 119-127 2016/11
Tyrphostin AG-related compounds attenuate H2O2-induced TRPM2-dependent and -independent cellular responses. 共著 J Pharmacol Sci., 134, 68-74 2017/05
Protective Effects of Duloxetine against Cerebral Ischemia-Reperfusion Injury via Transient Receptor Potential Melastatin 2 Inhibition. 共著 2019/02
Short TRPM2 prevents the targeting of full-length TRPM2 to the surface transmembrane by hijacking to ER associated degradation. 共著 Biochem Biophys Res Commun., 520, 520-525, 2019. 2019/10
Possible involvement of TRPM2 activation in 5-fluorouracil-induced myelosuppression in mice. 共著 Eur J Pharmacol., 891, 173671, 2021. doi : 10.1016/j.ejphar.2020.173671 2021/01
Mouse transient receptor potential melastatin 2 (TRPM2) isoform 7 attenuates full-length mouse TRPM2 activity through reductions in its expression by targeting it to ER-associated degradation./Joint Author/Genes cells, 29, 254-269/2024/01
表示を折りたたむ
その他の研究業績等
Role of tetrahydrobiopterin in the function of nitric oxide synthase, and its cytoprotective effect (Review). 共著 1998/11 Int. J. Mol. Med., 2, 533-540, 1998.
血管内皮由来過分極因子はK+？ 単著 1999/01 ファルマシア, 35, 944-945, 1999
Receptor-activated Ca2+ influx: capacitative Ca2+ entry and TRP proteins. 共著 1999/09 Nippon Yakurigaku Zasshi, 114, 149-160, 1999
Protective effect of tetrahydrobiopterin against reactive oxygen species- and nitric oxide-induced vascular endothelial cell injury. 単著 2002/01 Pteridines, 13, 32-37, 2002
Ca2+ channel alpha1B subunit (CaV 2.2) knockout mouse reveals a predominant role of N-type channels in the sympathetic regulation of the circulatory system. 共著 2002/06 Trends Cardiovasc. Med., 12, 270-274
全て表示する（8件）
TRPM2 チャネルによる活性酸素シグナルの増幅と慢性炎症の関連 共著 2009/01 日本薬理学雑誌 134, 122-126, 2009
酸化ストレス作動性TRPチャネルと消化管炎症 共著 2011/01 Journal of Gastrointestinal Research 19, 4-12, 2011
活性酸素感受性Ca2+透過性チャネルTRPM2の活性化による炎症反応の増幅 共著 2011/01 生化学 83, 1100-1103, 2011
表示を折りたたむ
主な担当授業科目名
薬理学Ⅰ
薬理学Ⅱ
薬学総括講義
薬の科学
動物薬理学Ⅱ
教育研究業績書情報（授業科目を担当する専任教員）：職務上の実績に関する事項
資格，免許
薬剤師免許
