研究者情報
本学における所属
最終学歴
現在所属している学会
学士･修士･博士等の学位
研究者活動情報
研究分野
主な研究項目
主な著書
主な論文
その他の研究業績等
主な担当授業科目名
教育研究業績書情報（授業科目を担当する専任教員）：職務上の実績に関する事項
資格，免許
基本情報
氏名
水間 俊
氏名（カナ）
ミズマ タカシ
氏名（英語）
Takashi Mizuma
所属
薬学部 薬学科
職名
教授
researchmap研究者コード
researchmap機関
本学における所属
帝京平成大学 薬学部 薬学科 教授
最終学歴
東京薬科大学大学院薬学研究科博士課程
現在所属している学会
・日本薬学会
・日本薬物動態学会
American Association of Pharmaceutical Scientists
情報計算化学生物学会（CBI学会）
日本DDS学会
全て表示する（8件）
日本薬学会
日本薬剤学会
日本薬物動態学会
表示を折りたたむ
学士･修士･博士等の学位
薬学士、薬学修士、薬学博士
研究者活動情報
研究分野
薬学
主な研究項目
飲食物成分の体内動態と相互作用
薬物の腸管における吸収と代謝 eADMET
主な著書
ADMET市販ソフトはどこまで有効か — e-ADMET構築に向けて３ — 単著 情報計算化学生物学会（2012）http://cbi-society.org/home/documents/eBook/eBook1.pdf 1900/01
創薬研究のストラテジー 共著 日本薬理学会編 金芳堂 2011/03
遺伝子医学MOOK 別冊 ペプチド・タンパク性医薬品の新規DDS製剤の開発と応用 共著 メディカルドゥ 2011/06
難吸収性薬物の吸収性改善と新規投与製剤の開発 共著 シーエムシー 2012/04
主な論文
Predictability of the covalent binding of acidic drugs in man. 共著 Life Sci., 53, PL141-146 1900/01
Transport mechanisms of a glycoside, p-nitrophenyl-β-D-glucopyranoside, across rat small intestinal brush-border membranes. 共著 Biochim. Biophys. Acta., 1370, 192-198 1900/01
Intestinal absorption and analgesic activity of cellobiose-coupled leucine enkephalinamide. 共著 Biopharm. Drug Dispos., 19, 605-610 1900/01
Intestinal absorption of acyclovir -glucoside: comparative study with acyclovir, guanosine and kinetin -glucoside. 共著 Pharm. Res., 16, 69-73 1900/01
Intestinal transport of -thioglycosides by Na+/glucose cotransporter. 共著 J. Pharm. Pharmacol., 52, 303-310 1900/01
全て表示する（53件）
Kinetic characterization of glycosidase activity from disaccharide conjugate to monosaccharide conjugate in Caco-2 cells. 共著 J Pharm Pharmacol. 57, 661-664 1900/01
Pharmacokinetic strategy for designing orally effective prodrugs overcoming biological membrane barriers: proposal of kinetic c 単著 Chem-Bio Informatics Journal, 8, 25-32 (2008) 1900/01
Integrated pharmacokinetic assessment and strategy for orally effective prodrugs overcoming luminal degradation and biological 単著 Chem-Bio Informatics Journal 8, 58-68 1900/01
Dietary polyphenols (-)-epicatechin and chrysin inhibit intestinal glucuronidation metabolism to increase drug absorption. 共著 J. Pharm. Sci. 93, 2407-2410 1900/01
Does the well-stirred model assess the intestinal first-pass effect well? 共著 J Pharm Pharmacol. 56, 1597-1599 1900/01
Correlation of drug conjugative metabolism rates between in vivo and in vitro: glucuronidation and sulfation of p-nitrophenol a 共著 J. Pharmacobio-Dyn. 5, 811-817 1900/01
High performance liquid chromatographic identificaiton and determination of photodegaradation and acyl migration products of fu 共著 J. Chromatogr. B., 718, 153-162 1900/01
Transport of acetaminophen conjugates in isolated rat hepatocytes. 共著 Dug Metab. Dispos., 17, 341-344 1900/01
Fluorescence energy transfer study of the relationship between the lone tryptophan residue and drug binding sites in human seru 共著 J. Pharm. Sci., 76, 387-392 1900/01
Comparative study of active absorption by the intestine and disposition of anomers of sugar conjugated compounds. 共著 Biochem. Pharmacol., 45, 1520-1523 1900/01
Predictive Performance of Vancomycin Trough Concentrations in Patients With Diabetes With Microalbuminuria. 共著 Ther Drug Monit. 39, 614-616 1900/01
Conformational change in plasma albumin due to interaction with isolated rat hepatocytes. 共著 Am. J. Physiol., 264, G456-470 1900/01
Inhibitory effect of phloridzin and phloretin on glucuronidation of p-nitrophenol, acetaminophen and 1-naphthol: kinetic demons 共著 Biochim. Biophys. Acta.,1425, 398-404 1900/01
Transport and recognition of aminopeptidase-resistant cellobiose-coupled tyrosyl-glycylglycine by intestinal Na+/glucose cotran 共著 Biol. Pharm. Bull. 22, 876-879 1900/01
Species and organ differences of sulphate conjugation of p-nitrophenol in liver and platelets. Chem. 共著 Chem. Pharm. Bull., 40, 1964-1965 1900/01
Differentiation of organ availability by sequential analysis and simultaneous analysis: intestinal conjugative metabolism impac 共著 J. Pharm. Sci. 94, 571-575 1900/01
Uptake of cyclic dipeptide by PEPT1 in Caco-2 cells: phenolic hydroxyl group of substrate enhances affinity for PEPT1 J. Pharm. 共著 J. Pharm. Pharmacol. 54, 1293-1296 1900/01
Intestinal absorption and analgesic activity of cellobiose-coupled leucine enkephalinamide. 共著 Biopharm. Drug Dispos., 19, 605-610 1900/01
Intestinal absorption of stable cyclic dipeptides by oligopeptide transporter. 共著 J. Pharm. Pharmacol., 50, 167-172 1900/01
Intestinal Na+/glucose cotransporter-mediated transport of glucose conjugate formed from disaccharide conjugate. Biochim. Bioph 共著 Biochim. Biophys. Acta., 1379, 1-6 1900/01
Intestinal absorption of lactonolactone-coupled tripeptide and stability in serum: effect of linkage between peptide and monosa 共著 Protein and Peptide Letters, 4, 115-122 1900/01
Preference of Peyer’s Patches to jejunal epithelium for intestinal absorption of oligopeptides, tyrosylglycylglycine and D-kyot 共著 Biol. Pharm. Bull., 20, 1024-1025 1900/01
Improvement of intestinal absorption of leucine enkephalin by sugar coupling and peptidase inhibitors. 共著 J. Pharm. Sci., 85, 854-857 1900/01
Transport of low and high molecular peptides across rabbit Peyer’s patches. 共著 Pharm. Res. 11, 361-364 1900/01
Na+-dependent transport of aminopeptidase-resistant sugar-coupled tripeptides in rat intestine. 共著 Biochem. Biophys. Res. Commun., 203, 1412-1416 1900/01
Intestinal absorption of stable cyclic glycylphenylalanine: comparison with the linear form. 共著 J. Pharm. Pharmacol., 49, 1067-1071 1900/01
Inhibition of the hepatic uptake of paracetamol sulphate by anionic compounds. 共著 J. Pharm. Pharmacol., 49, 743-746 1900/01
Cellulase-catalyzed transglucosylation of acetaminophen and acyclovir. 共著 Pharm. Res., 14, 1647-1650 1900/01
Sulphate conjugation enhances reversible binding of drug to human serum albumin. 共著 J. Pharm. Pharmacol., 43, 446-448 1900/01
Correlation of phenol sulfotransferase activities in the liver and platelets of rat. 共著 J. Pharm. Pharmacol., 42, 207-208 1900/01
Aryl sulfotransferase in rat liver: multiplicity and substrate specificity. 共著 J. Pharmacobio-Dyn., 10, 736-742 1900/01
Characterization of the interaction of albumin with isolated rat liver cells to reveal the mechanism of albumin-mediated hepati 共著 J. Pharmacobio-Dyn., 9, 244-248 1900/01
Heterogenous distribution of the conjugation activity of acetaminophen and p-nitrophenol in isolated rat liver cells. 共著 J. Pharmacobio-Dyn., 9, 218-222 ( 1900/01
The effect of albumin on the uptake of bromosulfophthalein by isolated rat hepatocytes. 共著 J. Pharmacobio-Dyn., 8, 90-94 1900/01
Heterogenous distribution of conjugation activities of harmol in isolated rat liver cells. 共著 J. Pharmacobio-Dyn., 7, 624-629 1900/01
p-Nirophenol sulfation in rat liver cytosol: multiple forms and substrate inhibition of aryl sulfotransferase. J. Pharmacobio-D 共著 J. Pharmacobio-Dyn., 6, 851-858 1900/01
p-Nitrophenol sulfate conjugation with substrate inhibition in rat liver cytosol fraction. 共著 Chem. Pharm. Bull., 31, 4565-4567 1900/01
Interaction of human serum albumin with furosemide glucuronide: a role of albumin in isomerization, hydrolysis, reversible bind 共著 Biopharm. Drug Dispos., 20, 131-136 1900/01
Factors influencing drug sulfate and glucuronic acid conjugation rate in isolated rat hepatocytes: significance of preincubatio 共著 Biochem. Pharmacol., 34, 2573-2575 1985/07
Intestinal active absorption of sugar-conjugated compounds by glucose transport system: implication of improvement of poorly ab 共著 Biochem. Pharmacol., 43, 2037-2039 1992/05
The β-anomeric and glucose preferences of glucose transport carrier for intestinal active absorption of monosaccharide conjugat 共著 Biochim. Biophys. Acta., 1200, 117-122 1994/07
Factors that cause β-anomeric preference of Na+/glucose cotransporter for intestinal transport of monosaccharide conjugates. 共著 Biochim. Biophys. Acta., 1381, 340-346 1998/08
Photoinduced covalent binding of furosemide and furosemide glucuronide to human serum albumin. 共著 Br. J. Clin. Pharmacol., 48, 79-87 1999/07
Assessment of presystemic and systemic intestinal availability of orally administered drugs using in vitro and in vivo data in 単著 J. Pharm. Sci. 97, 5471-5476 2008/12
腸管におけるグルクロン酸抱合代謝は、肝臓よりも経口バイオアベイラビリティに対してより大きな影響を与える 単著 Int. J. Pharm. 378, 140-141 2009/08
Kinetic assessment of luminal degradation of orally effective prodrugs for rational drug development. 単著 J. Pharm. Sci. 99, 1078-1086 2010/02
A Toxicity Risk Index, An Index for Warning Idiosyncratic Drug Toxicity 共著 J. Pharm. Sci, 102, 3447-3450 2013/09
Human serum albumin binding of 3, 5, 6, 7, 8, 3’, 4’-heptamethoxyflavone, a citrus flavonoid possessing a neuroprotective effec 共著 Chem-Bio Informatics Journal, 17, 103-109 2017/11
表示を折りたたむ
その他の研究業績等
大会報告 プレナリー講演 「育薬における副作用情報」 単著 1900/01 CBI学会誌 6（4）、5
未解明の薬物動態におけるタンパク結合のインパクト 単著 1900/01 CBI学会誌７（4）、39−40
主な担当授業科目名
生物薬剤学
薬物動態解析
薬剤学特論
薬学総括講義II
臨床薬学実習II
全て表示する（6件）
卒業研究
表示を折りたたむ
教育研究業績書情報（授業科目を担当する専任教員）：職務上の実績に関する事項
資格，免許
薬剤師免許
