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Basic information
| Name |
Takashi Mizuma |
| Belonging department |
Department of Pharmaceutical Sciences,Faculty of Pharmaceutical Sciences |
| Occupation name |
Professor |
| researchmap researcher code |
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| researchmap agency |
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Affiliation of Our College |
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Last Educational Background |
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The Academic Society which Belongs at Present |
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Researcher Activity Information
- Predictability of the covalent binding of acidic drugs in man. 共著 Life Sci., 53, PL141-146 1900/01
- Transport mechanisms of a glycoside, p-nitrophenyl-β-D-glucopyranoside, across rat small intestinal brush-border membranes. 共著 Biochim. Biophys. Acta., 1370, 192-198 1900/01
- Intestinal absorption and analgesic activity of cellobiose-coupled leucine enkephalinamide. 共著 Biopharm. Drug Dispos., 19, 605-610 1900/01
- Intestinal absorption of acyclovir -glucoside: comparative study with acyclovir, guanosine and kinetin -glucoside. 共著 Pharm. Res., 16, 69-73 1900/01
- Intestinal transport of -thioglycosides by Na+/glucose cotransporter. 共著 J. Pharm. Pharmacol., 52, 303-310 1900/01
- Kinetic characterization of glycosidase activity from disaccharide conjugate to monosaccharide conjugate in Caco-2 cells. 共著 J Pharm Pharmacol. 57, 661-664 1900/01
- Pharmacokinetic strategy for designing orally effective prodrugs overcoming biological membrane barriers: proposal of kinetic c 単著 Chem-Bio Informatics Journal, 8, 25-32 (2008) 1900/01
- Integrated pharmacokinetic assessment and strategy for orally effective prodrugs overcoming luminal degradation and biological 単著 Chem-Bio Informatics Journal 8, 58-68 1900/01
- Dietary polyphenols (-)-epicatechin and chrysin inhibit intestinal glucuronidation metabolism to increase drug absorption. 共著 J. Pharm. Sci. 93, 2407-2410 1900/01
- Does the well-stirred model assess the intestinal first-pass effect well? 共著 J Pharm Pharmacol. 56, 1597-1599 1900/01
- Correlation of drug conjugative metabolism rates between in vivo and in vitro: glucuronidation and sulfation of p-nitrophenol a 共著 J. Pharmacobio-Dyn. 5, 811-817 1900/01
- High performance liquid chromatographic identificaiton and determination of photodegaradation and acyl migration products of fu 共著 J. Chromatogr. B., 718, 153-162 1900/01
- Transport of acetaminophen conjugates in isolated rat hepatocytes. 共著 Dug Metab. Dispos., 17, 341-344 1900/01
- Fluorescence energy transfer study of the relationship between the lone tryptophan residue and drug binding sites in human seru 共著 J. Pharm. Sci., 76, 387-392 1900/01
- Comparative study of active absorption by the intestine and disposition of anomers of sugar conjugated compounds. 共著 Biochem. Pharmacol., 45, 1520-1523 1900/01
- Predictive Performance of Vancomycin Trough Concentrations in Patients With Diabetes With Microalbuminuria. 共著 Ther Drug Monit. 39, 614-616 1900/01
- Conformational change in plasma albumin due to interaction with isolated rat hepatocytes. 共著 Am. J. Physiol., 264, G456-470 1900/01
- Inhibitory effect of phloridzin and phloretin on glucuronidation of p-nitrophenol, acetaminophen and 1-naphthol: kinetic demons 共著 Biochim. Biophys. Acta.,1425, 398-404 1900/01
- Transport and recognition of aminopeptidase-resistant cellobiose-coupled tyrosyl-glycylglycine by intestinal Na+/glucose cotran 共著 Biol. Pharm. Bull. 22, 876-879 1900/01
- Species and organ differences of sulphate conjugation of p-nitrophenol in liver and platelets. Chem. 共著 Chem. Pharm. Bull., 40, 1964-1965 1900/01
- Differentiation of organ availability by sequential analysis and simultaneous analysis: intestinal conjugative metabolism impac 共著 J. Pharm. Sci. 94, 571-575 1900/01
- Uptake of cyclic dipeptide by PEPT1 in Caco-2 cells: phenolic hydroxyl group of substrate enhances affinity for PEPT1 J. Pharm. 共著 J. Pharm. Pharmacol. 54, 1293-1296 1900/01
- Intestinal absorption and analgesic activity of cellobiose-coupled leucine enkephalinamide. 共著 Biopharm. Drug Dispos., 19, 605-610 1900/01
- Intestinal absorption of stable cyclic dipeptides by oligopeptide transporter. 共著 J. Pharm. Pharmacol., 50, 167-172 1900/01
- Intestinal Na+/glucose cotransporter-mediated transport of glucose conjugate formed from disaccharide conjugate. Biochim. Bioph 共著 Biochim. Biophys. Acta., 1379, 1-6 1900/01
- Intestinal absorption of lactonolactone-coupled tripeptide and stability in serum: effect of linkage between peptide and monosa 共著 Protein and Peptide Letters, 4, 115-122 1900/01
- Preference of Peyer’s Patches to jejunal epithelium for intestinal absorption of oligopeptides, tyrosylglycylglycine and D-kyot 共著 Biol. Pharm. Bull., 20, 1024-1025 1900/01
- Improvement of intestinal absorption of leucine enkephalin by sugar coupling and peptidase inhibitors. 共著 J. Pharm. Sci., 85, 854-857 1900/01
- Transport of low and high molecular peptides across rabbit Peyer’s patches. 共著 Pharm. Res. 11, 361-364 1900/01
- Na+-dependent transport of aminopeptidase-resistant sugar-coupled tripeptides in rat intestine. 共著 Biochem. Biophys. Res. Commun., 203, 1412-1416 1900/01
- Intestinal absorption of stable cyclic glycylphenylalanine: comparison with the linear form. 共著 J. Pharm. Pharmacol., 49, 1067-1071 1900/01
- Inhibition of the hepatic uptake of paracetamol sulphate by anionic compounds. 共著 J. Pharm. Pharmacol., 49, 743-746 1900/01
- Cellulase-catalyzed transglucosylation of acetaminophen and acyclovir. 共著 Pharm. Res., 14, 1647-1650 1900/01
- Sulphate conjugation enhances reversible binding of drug to human serum albumin. 共著 J. Pharm. Pharmacol., 43, 446-448 1900/01
- Correlation of phenol sulfotransferase activities in the liver and platelets of rat. 共著 J. Pharm. Pharmacol., 42, 207-208 1900/01
- Aryl sulfotransferase in rat liver: multiplicity and substrate specificity. 共著 J. Pharmacobio-Dyn., 10, 736-742 1900/01
- Characterization of the interaction of albumin with isolated rat liver cells to reveal the mechanism of albumin-mediated hepati 共著 J. Pharmacobio-Dyn., 9, 244-248 1900/01
- Heterogenous distribution of the conjugation activity of acetaminophen and p-nitrophenol in isolated rat liver cells. 共著 J. Pharmacobio-Dyn., 9, 218-222 ( 1900/01
- The effect of albumin on the uptake of bromosulfophthalein by isolated rat hepatocytes. 共著 J. Pharmacobio-Dyn., 8, 90-94 1900/01
- Heterogenous distribution of conjugation activities of harmol in isolated rat liver cells. 共著 J. Pharmacobio-Dyn., 7, 624-629 1900/01
- p-Nirophenol sulfation in rat liver cytosol: multiple forms and substrate inhibition of aryl sulfotransferase. J. Pharmacobio-D 共著 J. Pharmacobio-Dyn., 6, 851-858 1900/01
- p-Nitrophenol sulfate conjugation with substrate inhibition in rat liver cytosol fraction. 共著 Chem. Pharm. Bull., 31, 4565-4567 1900/01
- Interaction of human serum albumin with furosemide glucuronide: a role of albumin in isomerization, hydrolysis, reversible bind 共著 Biopharm. Drug Dispos., 20, 131-136 1900/01
- Factors influencing drug sulfate and glucuronic acid conjugation rate in isolated rat hepatocytes: significance of preincubatio 共著 Biochem. Pharmacol., 34, 2573-2575 1985/07
- Intestinal active absorption of sugar-conjugated compounds by glucose transport system: implication of improvement of poorly ab 共著 Biochem. Pharmacol., 43, 2037-2039 1992/05
- The β-anomeric and glucose preferences of glucose transport carrier for intestinal active absorption of monosaccharide conjugat 共著 Biochim. Biophys. Acta., 1200, 117-122 1994/07
- Factors that cause β-anomeric preference of Na+/glucose cotransporter for intestinal transport of monosaccharide conjugates. 共著 Biochim. Biophys. Acta., 1381, 340-346 1998/08
- Photoinduced covalent binding of furosemide and furosemide glucuronide to human serum albumin. 共著 Br. J. Clin. Pharmacol., 48, 79-87 1999/07
- Assessment of presystemic and systemic intestinal availability of orally administered drugs using in vitro and in vivo data in 単著 J. Pharm. Sci. 97, 5471-5476 2008/12
Intestinal glucuronidation metabolism may have a greater impact on oral bioavailability than hepatic glucuronidation metabolism in humans:
A study with raloxifene, substrate for UGT1A1, 1A8, 1A9, and 1A10 /Sole Author/International Journal of Pharmaceutics/2009/08- Kinetic assessment of luminal degradation of orally effective prodrugs for rational drug development. 単著 J. Pharm. Sci. 99, 1078-1086 2010/02
- A Toxicity Risk Index, An Index for Warning Idiosyncratic Drug Toxicity 共著 J. Pharm. Sci, 102, 3447-3450 2013/09
- Human serum albumin binding of 3, 5, 6, 7, 8, 3’, 4’-heptamethoxyflavone, a citrus flavonoid possessing a neuroprotective effec 共著 Chem-Bio Informatics Journal, 17, 103-109 2017/11
Other Research Achievements |
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Education research achievement book information (full-time teacher in charge of course subjects): Matters related to job performance
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