研究者情報
本学における所属
最終学歴
現在所属している学会
学士･修士･博士等の学位
研究者活動情報
研究分野
主な研究項目
主な著書
主な論文
その他の研究業績等
主な担当授業科目名
教育研究業績書情報（授業科目を担当する専任教員）：職務上の実績に関する事項
資格，免許
基本情報
氏名
高崎 浩太郎
氏名（カナ）
タカサキ コウタロウ
氏名（英語）
Kotaro Takasaki
所属
薬学部 薬学科
職名
准教授
researchmap研究者コード
researchmap機関
本学における所属
帝京平成大学 薬学部 薬学科 准教授
最終学歴
東京薬科大学大学院薬学研究科薬学専攻博士前期課程
現在所属している学会
日本神経精神薬理学会
日本糖尿病学会
日本毒性学会
日本薬学会
日本薬理学会
全て表示する（6件）
日本睡眠学会
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学士･修士･博士等の学位
学士（薬学）
修士（薬学）
博士（薬学）
研究者活動情報
研究分野
薬学
主な研究項目
消化管運動改善薬の探索研究
糖尿病治療薬の探索・開発研究
開発候補化合物の中枢安全性薬理評価
遺伝子改変動物の行動薬理学的表現型解析
漢方方剤の薬理学的作用機序解析
全て表示する（6件）
低分子化合物の薬理学的作用機序解析
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主な著書
わかりやすい疾患と処方薬の解説－薬物治療編－ 共著 アークメディア 2018/03
主な論文
Involvement of the active metabolites in the inhibitory activity of K579 on rat plasma dipeptidyl peptidase IV/Joint Author/European Journal of Pharmacology/2004/11
Glucose concentration-dependent potentiation of insulin secretion by a new chemical entity, KCP256/Joint Author/European Journal of Pharmacology/2005/12
K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting hypoglycemic agent/Joint Author/European Journal of Pharmacology/2004/02
Change of the involvement of 5-HT3 receptor in the gastric motor stimulating actions of KW-5139 (Leu13-motilin acetate) in the recovered and post-operative periods in dogs/Joint Author/Life Sciences/2000/09
Recovery of gastrointestinal motility from post-operative ileus in dogs: effects of Leu13-motilin (KW-5139) and prostaglandin F2 alpha/Joint Author/Neurogastroenterology & Motility/1995/12
全て表示する（48件）
Effects of KW-5092, a novel gastroprokinetic agent, on the delayed colonic propulsion in rats/Joint Author/Japanese Journal of Pharmacology/1994/03
Inhibition by indomethacin of the already accelerated secretion of inhibin and estradiol in equine chorionic gonadotropin-primed immature female rats/Joint Author/Biological & Pharmaceutical Bulletin/1993/05
A role of prostaglandin in the secretion of inhibin and oestradiol-17 beta in equine chorionic gonadotrophin-primed rats/Joint Author/European Journal of Pharmacology/1993/02
Indomethacin inhibits the secretion of inhibin and oestradiol-17 beta stimulated by pregnant mare serum gonadotrophin in the im/Joint Author/European Journal of Pharmacology/1992/10
Inhibitory and stimulatory actions of danazol in rat ovarian and uterine tissues/Joint Author/European Journal of Pharmacology/1992/01
Effects of combination treatment with dipeptidyl peptidase IV inhibitor and sulfonylurea on glucose levels in rats/Joint Author/Journal of Pharmacological Sciences/2004/04
Ameliorative Effects of Telmisartan on the Inflammatory Response and Impaired Spatial Memory in a Rat Model of Alzheimer’s Disease Incorporating Additional Cerebrovascular Disease Factors/Joint Author/Biol Pharm Bull/2012/12
Effect of hachimijiogan on memory impairment induced by beta-amyloid combined with cerebral ischemia in rats/Joint Author/Traditional & Kampo Medicine/2017/04
Ameliorative effect of sansoninto on sleep disturbance and spatial memory impairment in an Alzheimer's disease rat model/Joint Author/Traditional & Kampo Medicine/2017/04
Pharmacological evidence for the clinical effectiveness of Kampo drugs/Joint Author/Folia Pharmacologica Japonica/2014/05
Pharmacological studies for the ameliorative effects of yokukansan on memory deficits and abnormal behavior in an animal model/Joint Author/Folia Pharmacol. Jpn./2012/05
Effect of Yokukansan on memory disturbance in an animal model of cerebrovascular dementia/Joint Author/Journal of Traditional Medicines/2013/10
Cholinergic involvement and synaptic dynamin 1 expression in Yokukansan-mediated improvement of spatial memory in a rat model of early Alzheimer's disease
/Joint Author/Phytotherapy Ressearch/2013/07
Yokukansan, a traditional Japanese herbal medicine, promotes neurite outgrowth in PC12 cells through the activation of extracellular signal regulated kinase 1/2 and phosphatidylinositol 3-kinase/Akt/Joint Author/Journal of Traditional Medicines/2013/05
Facilitation of memory impairment and cholinergic disturbance in a mouse model of Alzheimer's disease by mild ischemic burden/Joint Author/Neurosci Lett/2013/02
クエチアピンフマル酸塩錠（クエチアピン錠「NP」およびセロクエル®錠）の実験的統合失調症モデルマウスにおける行動薬理作用の比較 共著 新薬と臨牀 2013/01
Pharmacological studies for the ameliorative effects of yokukansan on memory deficits and abnormal behavior in an animal model of dementia/Joint Author/Folia Pharmacol. Jpn./2012/08
Influence of Telmisartan as a PPARγ Partial Agonist on Neuronal Cell-death and Memory Impairment Induced by Cerebral Ischemia in Rats/Joint Author/Therapeutic Res/2012/05
Long-Term Culture of Astrocytes Attenuates the Readily Releasable Pool of Synaptic Vesicles/Joint Author/PLoS ONE/2012/10
Cerebroprotective action of telmisartan by inhibition of macrophages/microglia expressing HMGB1 via a peroxisome proliferator-a/Joint Author/Neurosci Lett/2009/10
Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism/Joint Author/Neuropharmacology/2008/12
Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)
2A
receptors in the prefrontal cortex/Joint Author/Prog Neuropsychopharmacol Biol Psychiatry/2008/08
ドネペジル塩酸塩OD錠「NP」のアルツハイマー病モデルラットの空間記憶障害に対する改善作用 共著 新薬と臨床 2012/03
Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti/Joint Author/Proc Natl Acad Sci U S A/2009/05
Effects of yokukansan on anxiety-like behavior in a rat model of cerebrovascular dementia/Joint Author/J Nat Med/2010/12
Yokukansan inhibits social isolation-induced aggression and methamphetamine-induced hyperlocomotion in rodents/Joint Author/Biol Pharm Bull/2008/12
Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease/Joint Author/Brain Res/2009/01
Dynamin 1 depletion and memory deficits in rats treated with A-beta and cerebral ischemia/Joint Author/J Neurosci Res/2010/07
Telmisartan, a partial agonist of peroxisome proliferator-activated receptor γ, improves impairment of spatial memory and hippocampal apoptosis in rats treated with repeated cerebral ischemia
/Joint Author/Brain Research/2010/09
Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABAA - Benzodiazepine Receptor complex/Joint Author/J Pharmacol Sci/2011/06
Neuroprotective Effects of Citidine-5-diphosphocholine on Impaired Spatial Memory in a Rat Model of Cerebrovascular Dementia/Joint Author/J Pharmacol Sci/2011/05
Citidine-5-diphosphocholine ameriorates the impairment of spatial memory induced by scopolamine/Joint Author/J Health Sci/2011/07
Spatial memory impairment without apoptosis induced by the combination of beta-amyloid oligomers and cerebral ischemia is relat/Joint Author/J Pharmacol Sci/2008/01
Activation of Rheb, but not of mTORC1, impaires spine synapse morphogenesis in tuberous sclerosis complex/Joint Author/Scientific Reports/2014/06
Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex/Joint Author/Nat Commun/2015/04
Overexpression of Swedish mutant APP in aged astrocytes attenuates excitatory synaptic transmission/Joint Author/Physiol Rep/2016/01
Behavioral defects in a DCTN1G71A transgenic mouse model of Perry syndrome/Joint Author/Neurosci Lett/2018/02
The Japanese Angelica acutiloba root and yokukansan increase hippocampal acetylcholine level, prevent apoptosis and improve memory in a rat model of repeated cerebral ischemia/Joint Author/J Ethnopharmacol/2017/12
Extract of Yokukansan improves anxiety-like behavior and increases serum brain-derived neurotrophic factor in rats with cerebral ischemia combined with amyloid-42 peptide
/Joint Author/J Tradit Chin Med/2019/02
Behavioral defects in a DCTN1G71A transgenic mouse model of Perry syndrome/Joint Author/Neuroscience Letters/2014/02
脳由来神経栄養因子の発現誘導作用を介した抑肝散のアルツハイマー病モデル動物の不安様行動に対する効果 共著 臨床と研究 2014/11
アルツハイマー病新規治療戦略を指向した異常老化アストロサイトに関する研究 臨床と研究 2014/11
Effect of Yokukansan on sleep disturbance in a rat model of cerebrovascular dementia/Joint Author/Traditional & Kampo Medicine/2014/12
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その他の研究業績等
CDKAL1
欠損による誤翻訳を解消するエペリゾン誘導体の合成と血糖値上昇抑制作用
日本薬学会第144年会
主な担当授業科目名
薬物治療学
教育研究業績書情報（授業科目を担当する専任教員）：職務上の実績に関する事項
資格，免許
薬剤師免許
