Other Research Achievements

Basic information

Name Ken'ichi Ohno
Belonging department Department of Pharmaceutical Sciences,Faculty of Pharmaceutical Sciences
Occupation name Associate Professor
researchmap researcher code
researchmap agency


Recent development of chemical derivatization in LC-MS for biomedical approches

Sole or Joint Author

Joint Author

Date of Issue


Conference Presentation(name)

Bioanalysis, 7, 2489-99 (2015).


Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) is currently the most powerful system in biomedical analysis. At the same time, chemical derivatization is a useful technique to enhance the detection sensitivity of non- or poorly ionizable molecules in LC-MS/MS. Derivatization improves the ionization efficiency, the chromatographic separation and/or the chemical stability. This review presents an overview of the recent development of chemical derivatization reagents and reactions for the quantitative analysis of xenobiotic and endogenous molecules such as pharmaceuticals, amino acids, peptides, proteins, steroids, biomarkers and industrial products by LC-MS.