Study of cancer gene theapy using IL-12-secreting endothelial progenitor cells in a rat solid tumor model

IL-12 gene transfection of TR-BME-2 cells with a virus vector in vitro, and used the resultant IL-12-secreting TR-BME-2 to deliver IL-12, which strongly activates cytotoxic lymphocytes and natural killer cells, to the tumor site in vivo.

Oncol Rep.2003 10(6):1765-9.