Papers

Basic information

Name Shoichi Komine
Belonging department Department of Acupuncture and Moxibustion,Faculty of Health Care
Occupation name Assistant Professor
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Title 

Macrophage specific restoration of the Nrf2 gene in whole-body knockout mice ameliorates steatohepatitis induced by lipopolysaccharide from Porphyromonas gingivalis through enhanced hepatic clearance

					

					

						

							

								

									
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Joint Author

					

					

						

							

								

									
Summary 

									
								

							

						

						
Lipopolysaccharides (LPS) from Porphyromonas gingivalis (P.g.), which cause periodontal disease, contribute to the development of non-alcoholic steatohepatitis (NASH). After administering a high-fat diet for 18 weeks and intraperitoneal injections of P.g.-derived LPS for 6 weeks, it was suggested that Nrf2 in macrophages might play a crucial role in suppressing hepatic inflammation caused by P.g.

					

					

						

							

								

									
Magazine(name) 

									
								

							

						

						
PLoS One 2023 Oct 20;18(10):e0291880.

					

					

						

							

								

									
Date of Issue 

									
								

							

						

						
202310