Papers

Basic information

Name Takashi Izumi
Belonging department Department of Acupuncture and Moxibustion,Faculty of Health Care
Occupation name Professor
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Title 

PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice (査読付)

					

					

						

							

								

									
Bibliography　Type 

									
								

							

						

						
Joint Author

					

					

						

							

								

									
Summary 

									
								

							

						

						
HNF4α regulates various genes to maintain liver function.  In this study, liver-specific Hnf4a-deficient mice developed hepatosteatosis and liver fibrosis, and they were found to have difficulty utilizing glucose. These insights may contribute to the development of new diagnostic and therapeutic approaches for NAFLD by focusing on the HNF4α and PPARα signaling cascade.

					

					

						

							

								

									
Magazine(name) 

									
								

							

						

						
The Journal of Biochemistry                        

					

					

						

							

								

									
Date of Issue 

									
								

							

						

						
202301