Papers

Basic information

Name Manabu Shimazaki
Belonging department Department of Pharmaceutical Sciences,Faculty of Pharmaceutical Sciences
Occupation name Professor
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Title 

FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis.

					

					

						

							

								

									
Bibliography　Type 

									
								

							

						

						
Joint Author

					

					

						

							

								

									
Summary 

									
								

							

						

						
Cultivated mulberry cells, for which the presence of an enzyme (MaDA) that catalyzes the intermolecular Diels–Alder reaction has been suggested, produce enantioselectively secondary metabolites in high yields, but density functional theory calculations and speed Analysis of theoretical isotopic effects demonstrated that it catalyzes intermolecular Diels–Alder reactions.

					

					

						

							

								

									
Magazine(name) 

									
								

							

						

						
Nature Chemistry

					

					

						

							

								

									
Date of Issue 

									
								

							

						

						
202005