Papers

Basic information

Name Kotaro Takasaki
Belonging department Department of Pharmaceutical Sciences,Faculty of Pharmaceutical Sciences
Occupation name Associate Professor
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Title 

K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting hypoglycemic agent

					

					

						

							

								

									
Bibliography怀Type 

									
								

							

						

						
Joint Author

					

					

						

							

								

									
Summary 

									
								

							

						

						
The aim of present study was to characterize the pharmacological profiles of K579. During repetitive glucose loading using Zucker fatty rats, pretreatment with K579 attenuated the glucose excursion after the first and second glucose loading. The kinetic study revealed that K579 was a more potent and slower binding inhibitor than the existing dipeptidyl peptidase IV inhibitor, NVP-DPP728.

					

					

						

							

								

									
Magazine(name) 

									
								

							

						

						
European Journal of Pharmacology

					

					

						

							

								

									
Date of Issue 

									
								

							

						

						
200402