Papers

Basic information

Name Kazuma Aoki
Belonging department Department of Pharmaceutical Sciences,Faculty of Pharmaceutical Sciences
Occupation name Lecturer
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Title 

LARP1 specifically recognizes the 3' terminus of poly(A) mRNA.

					

					

						

							

								

									
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Summary 

									
								

							

						

						
Using proteomics, we identified LARP1 that interact to the 3' terminus of the poly(A) tail.  We also reveal that LARP1 stabilizes multiple mRNAs carrying 5' terminal oligopyrimidine tract (5'TOP). Our findings suggest that LARP1 may be involved in the post-transcriptional regulation of gene expression, at least in several 5'TOP mRNAs, through the binding to 3' terminus of the poly(A) tail.

					

					

						

							

								

									
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Date of Issue 

									
								

							

						

						
201307