Papers

Basic information

Name Mikiko Takahashi
Belonging department Department of Pharmaceutical Sciences,Faculty of Pharmaceutical Sciences
Occupation name Professor
researchmap researcher code
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Title 

LRBA is essential for urinary concentration and body water homeostasis.

					

					

						

							

								

									
Bibliography　Type 

									
								

							

						

						
Joint Author

					

					

						

							

								

									
Summary 

									
								

							

						

						
Water transport via aquaporin-2 (AQP2) is a critical determinant of urine volume. Antidiuretic hormone vasopressin activates renal PKA that phosphorylates AQP2, leading to AQP2 translocation from intracellular vesicles to the plasma membrane. We found that LRBA was essential for AQP2 phosphorylation. We furthermore identified that the LRBA–PKA interaction is a drug target for polyuria.

					

					

						

							

								

									
Magazine(name) 

									
								

							

						

						
Proc Natl Acad Sci U S A.

					

					

						

							

								

									
Date of Issue 

									
								

							

						

						
202210