Papers

Basic information

Name Yuichiro Taira
Belonging department Department of Pharmaceutical Sciences,Faculty of Pharmaceutical Sciences
Occupation name Professor
researchmap researcher code
researchmap agency

Title 

Potential Anti-Cancer Therapeutic Agents: Effects of VHH Antibodies on Mesothelin Binding Affinity in Cancer

					

					

						

							

								

									
Bibliography怀Type 

									
								

							

						

						
Joint Author

					

					

						

							

								

									
Summary 

									
								

							

						

						
Two anti-MSLN VHH mAb clones(MT1A1 and MT3C2), targeting the extracellular domain of human MSLN, recognize the region(296-390) at the N-terminal of MSLN on the cell surface and relying on their conformation-dependent recognition. MT1A1 and MT3C2 significantly inhibited the MSLN-CA125 interaction. Overall, our results suggest that MT1A1 and MT3C2 are promising anticancer agents.

					

					

						

							

								

									
Magazine(name) 

									
								

							

						

						
BPB Reports

					

					

						

							

								

									
Date of Issue 

									
								

							

						

						
202412