Papers

Basic information

Name Naho Maruyama
Belonging department Department of Health and Dietetics,Faculty of Health and Medical Science
Occupation name Professor
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Title 

Heterolytic oxygen-oxygen bond cleavage of peroxy acid and effective alkane hydroxylation in hydrophobic solvent mediated by an iron porphyrin coordinated by thiolate anion as a model for cytochrome P-450

					

					

						

							

								

									
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Joint Author

					

					

						

							

								

									
Summary 

									
								

							

						

						
Steroid biosynthesis and metabolism of aliphatic xenobiotics in biological systems involve alkane hydroxylation processes which are mediated by the ubiquitous cytochrome P-450. We report here that P-450 model cleaves the 0-0 bond of peroxy
acids heterolytically and the formed active intermediate can efficiently hydroxylate aliphatic hydrocarbons.

					

					

						

							

								

									
Magazine(name) 

									
								

							

						

						
Journal of the American Chemical Society

					

					

						

							

								

									
Date of Issue 

									
								

							

						

						
199301