By changing the flow rate from 1 L/min to 4 L/min and varying the infusion cannula position among the inferior vena cava (IVC), right atrium (RA), and superior vena cava (SVC), we investigated whether circulatory support could meet systemic organ demands for oxygen delivery and carbon dioxide removal by measuring recirculation rate, arterial oxygen saturation (SaO2), arterial oxygen partial pressure (PaO2), and arterial carbon dioxide partial pressure (PaCO2). The optimal drainage cannula site was found to be the SVC.