Since the 1960s, blood purification device development has focused on solute removal, water permeability, and biocompatibility. While the JSDT's "Performance Evaluation 2012" standardizes performance testing, biocompatibility evaluation lacks standardization. This study examines in vitro biocompatibility assessment methods, focusing on their advantages and disadvantages. In vitro testing requires choosing ① the test module (often commercial devices or mini-modules) and ② the test solution (typically whole human or animal blood). Careful consideration of each method's pros and cons is essential.
